Chromosome abnormalities in chronic active hepatitis

Chronic Hepatitis/Chronic Active Hepatitis in Dogs

Chromosome abnormalities in peripheral blood cells of hepatitis B virus chronic carriers.

Cytogenetic analysis of metaphase chromosome spreads from peripheral blood cells of hepatitis B virus (HBV) chronic carriers and HBV-negative individuals of the same ethnic origin revealed a significantly higher incidence of chromosome breaks and other mitotic aberrations in the HBV chronic carriers. The highest incidence of chromosome breaks was found in chronic carriers who evidenced circulat...

Involvement in Chronic Active Hepatitis

Rabbit liver plasma membranes were isolated and purified by using an aqueous twophase polymer system. Examination of these preparations with respect to electronmicroscopical appearance, distribution of marker enzymes and gross biochemical composition revealed them to be free from contamination by intracellular components. Sera from ten patients with chronic active hepatitis, four with and six w...

Chronic Active Hepatitis

Our previous observations of highly significant increases in high titre antibodies to measles and rubella in patients with chronic active hepatitis have been extended and it has been shown that these reactions do not occur in other forms of liver disease. Significant increases in antibody titres to cytomegalovirus have also been found in patients with chronic active hepatitis (p<0001) and alcoh...

Active chronic hepatitis. Part I.

IN 1950 Waldenstrom first drew attention to the occurrence of a form of chronic liver disease in young people, predominantly adolescent girls, in whom there was moderate jaundice, enlargement of the liver and spleen, acne, amenorrhoea and hyperglobulinaemia. The occurrence of fever, arthralgia and Cushingoid features was noted (Kunkel et al 1951, Beam et al 1956), the LE cell phenomenon was rep...